159RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF REBAMIPIDERebamipide is widely used to treat gastric ulcers and mucosal damage, so its quantification in pharmaceutical formulations requires accurate and reliable methods. An RP-HPLC method for the estimation of Rebamipide in tablet dosage forms will be developed and validated in this study. Chromatographic separation was carried out on a C18 column using methanol and water as a mobile phase. The pH was adjusted to an optimal level and a suitable UV wavelength was employed for detection. Evaluations of specificity, linearity, accuracy, precision, limit of detection (LOD), limit of quantification (LOQ), and robustness were conducted as part of the method validation process. The RP-HPLC method developed met all validation criteria and exhibited excellent performance over a specified concentration range and minimal variability, thus confirming its suitability for routine analysis of Rebamipide in pharmaceutical dosage forms.srijanomula007@gmail.comResearch1512025RP-HPLC, Method Development, Validation, RebamipideNomula Srija* Rajitha SKLR Pharmacy College, Paloncha, Bhadradri Kothagudem, Telangana- 507511, India