142ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF ESSENTIAL OILSThe use of natural drugs based on essential oils (EO) is now a days arousing great interest. Indeed, EO are showing high efficiency as antioxidants and anti-inflammatory drugs within the human organism. The aim of this study was to evaluate the biological activities of 9 EO isolated from angelica (roots and seeds), chives, chervil, garlic, leek, onion, shallots and thuya plants, in the presence and absence of hydroxypropyl-β-cyclodextrin (HP-β-CD). 1) EO antioxidant properties, assessed by DPPH assay, and 2) anti-inflammatory activities were determined thanks to the inhibition of albumin denaturation test. Our results showed that angelica seeds EO presented the highest antioxidant activity (IC50=0.05g.L-1 ) while the thuya EO has the lowest (IC50=6.7 g.L-1 ). Whereas highest anti-inflammatory activity was obtained by angelica seeds EO (IC50=0.42 g.L-1 ) while garlic EO (IC50=52.3 g.L-1 ) presented the lowest one. The presence of HP-β-CD did not significantly improve the EO biological activities. Our findings evidenced that EO coming from shallots, onions and angelica seeds are of interest to be used as antioxidant and anti-inflammatory additives. However, the encapsulation of EO in HP-βCD was not of interest at tested biological activities in our experimental conditions.lounes@univ-littoral.frResearch822018Essential Oil, Antioxidant, Anti-Inflammatory, Plant Extracts.Imad El-Alam,Anthony. Verdin,Joël Fontaine, Sophie Fourmentin,Ramez Chahine,Hassane Makhlouf,Anissa Lounès-Hadj SahraouiImad El-Alam,Anthony. Verdin,Joël Fontaine, Sophie Fourmentin,Ramez Chahine,Hassane Makhlouf,Anissa Lounès-Hadj Sahraoui