EVALUATION OF NEUROBEHAVIORAL EFFECTS OF ACRYLAMIDE UNDER FUNCTIONAL OBSERVATIONAL BATTERY (FOB) IN RATS ON REPEATED ORAL EXPOSURE
B. Ramya Sree
Department of Biotechnology, Sree Vidyanikethan Engineering College, Tirupati
Jyothi M. Joy
Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati
Acrylamide is a vinyl monomer with established neurotoxic effects. The important source for human exposure to acrylamide is occupational and other exposure sources include drinking water, smoking and foods cooked at high temperatures. In present study we evaluated the effects of acrylamide on neurobehavioral and locomotor functions under standard, validated test battery in wistar rats. Acrylamide administration at dose level of 40 mg/kg body weight for 14 days in both male and female rats induced significant characteristic neurotoxic symptoms including gait abnormalities, increased foot splay, decrease in grip strength and decrease in locomotor activity.
5 , 1 , 2015
22 - 28