PROCONVULSIVE POTENTIAL OF SOME FLUOROQUINOLONES ALONE AND WITH PARACETAMOL OR NIMESULIDE IN MICE
B. Ramya Sree
Department of Biotechnology, Sree Vidyanikethan Engineering College, Tirupati
Jyothi M. Joy
Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati
The incidence of CNS adverse reaction with fluoroquinolones was 0.4 -4.4%. However, reports of neurological disturbances such as convulsion are rare. It is reported that some Prostaglandins synthesis inhibitors have lowered the threshold for convulsion. Nimesulide alone induce convulsion in high doses. Paracetamol is used generally in infections associated with fever and pain. Objectives of the present study i. to compare the epileptogenic potential of fluoroquinolones, ii. To compare that Nimesulide and paracetamol have any effect on epileptogenic potential of fluoroquinolones. Maximal electroshock seizures method and Pentylenetetrazole (PTZ) induced seizures method are used. Proconvulsive activity is increased with fluoroquinolone alone and in combination with paracetamol or nimesulide as compared to vehicle. Results of this study it has been seen that norfloxacin have more epileptogenic potential than sparfloxacin & sparfloxacin norfloxacin have more epileptogenic potential than ciprofloxacin. (i.e.N>S>C). When these quinolones were combined with paracetamol or nimesulide the potentiation of proconvulsive activity was observed but was not statically in significant. Hence fluoroquinolones should be prescribed cautiously in patients with history of convulsions. Patients who are also receiving NSAIDs should be carefully documented and administered fluoroquinolone carefully.
4 , 2 , 2014
104 - 108