ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF ESSENTIAL OILS
B. Ramya Sree
Department of Biotechnology, Sree Vidyanikethan Engineering College, Tirupati
Jyothi M. Joy
Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati
The use of natural drugs based on essential oils (EO) is now a days arousing great interest. Indeed, EO are showing high efficiency as antioxidants and anti-inflammatory drugs within the human organism. The aim of this study was to evaluate the biological activities of 9 EO isolated from angelica (roots and seeds), chives, chervil, garlic, leek, onion, shallots and thuya plants, in the presence and absence of hydroxypropyl-β-cyclodextrin (HP-β-CD). 1) EO antioxidant properties, assessed by DPPH assay, and 2) anti-inflammatory activities were determined thanks to the inhibition of albumin denaturation test. Our results showed that angelica seeds EO presented the highest antioxidant activity (IC50=0.05g.L-1 ) while the thuya EO has the lowest (IC50=6.7 g.L-1 ). Whereas highest anti-inflammatory activity was obtained by angelica seeds EO (IC50=0.42 g.L-1 ) while garlic EO (IC50=52.3 g.L-1 ) presented the lowest one. The presence of HP-β-CD did not significantly improve the EO biological activities. Our findings evidenced that EO coming from shallots, onions and angelica seeds are of interest to be used as antioxidant and anti-inflammatory additives. However, the encapsulation of EO in HP-βCD was not of interest at tested biological activities in our experimental conditions.
8 , 2 , 2018
12 - 16