CYTOPATHOLOGICAL STUDY OF NEUROFIBRILLARY TANGLES IN CEREBRAL CORTEX AND HIPPOCAMPUS OF SWISS ALBINO MOUSE: MUS MUSCULUS
B. Ramya Sree
Department of Biotechnology, Sree Vidyanikethan Engineering College, Tirupati
Jyothi M. Joy
Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati
Age related memory deficit is commonly observed in elderly population. The strategies of drug designing for senile dementia and Alzheimer’s disease are based on the advances in understanding the molecular organization of neurons and synapse, biochemistry of neuronal signaling and impulse transmission. Various anti-dementia drugs and nootropic drugs are available, such as cholinesterase inhibitors and NMDA receptor antagonists. However, patients did not get significant relief by these therapeutic strategies. Probably, maintaining the healthy cytoarchitecture of neurons may be a more promising approach in the treatment of neurodegenerative diseases. One of the neuropathological alterations is the deposition of neurofibrillary tangles (NFTs). These are aggregates of paired helical filaments that interfere in axonal transport and thus affect neuronal functions. In the present investigations we have studied the deposition of NFTs by silver staining method in the cerebral cortex and hippocampus of Swiss albino mouse Mus musculus after 6, 12, 18 and 24 months of age. We have observed no deposition of NFTs at 6 months of age in both the regions under study. There was progressive deposition of NFTs in cerebral cortex from 12 to 18 months and 18 to 24 months, whereas, in the hippocampal region there was gradual increase in the deposition of NFTs.
5 , 4 , 2015
314 - 319