The concentration of heavy metals in the water which may affects the human health and the health of aquatic ecosystem were determine in Godavari river water. Water samples collected from the selected sites of Godavari River at Nanded for determination of heavy metals. For the detection of heavy metals using standard methods suggested by APHA, 1995 and NEERI, 1988. The results of the heavy metals were obtained in the following range Fe 0.254 to 0.537 mg/l at site I, 0.254 to 0.478 mg/l at Site- II and 0.233 to 0.465 mg/l at site – III, Cu 0.0248 to 0.0550 mg/l at site I,0.0249 to 0.0599 mg/l at Site- II and 0.0249 to 0.0567 mg/l at site – III, Mn 0.021 to 0.055 mg/l at site I, 0.020 to 0.050mg/l at Site- II and 0.022 to 0.051 mg/l at site – III, and Zn 0.60 to 0.83mg/l at site-I, 0.58 to 0.72 mg/l at site- II and 0.52 to 0.77 mg/l at site III respectively. The above heavy metal is selected for the study because it cause pollution in river water and it is highly toxic to the aquatic animals or flora and fauna. The concentration of these parameters of pollution contained in the study area indicated the river is fairly polluted. It may be due to the mixing of domestic sewage, agricultural waste and surface runoff water in the river.