Platelet files are conceivably valuable markers for the early conclusion of thromboembolic diseases.MPV and PDW help in segregating reasons for thrombocytopenia as hypoproductive or hyperdestructive like invulnerable thrombocytopenic purpura. Mean platelet volume (MPV) and platelet circulation width (PDW) are valuable in the differential analysis of aplastic weakness and idiopathic thrombocytopenic purpura. An expansion in both mean platelet volume (MPV) and platelet circulation width (PDW) because of platelet initiation, was proposed because of Platelet swelling,Pseudopodia arrangement. MPV and PDW are basic platelet files, which increment during platelet enactment. MPV is a machine-determined estimation of the normal size of platelets found in blood and is commonly remembered for blood tests as a component of the CBC. Essentially with thrombocytopenia when it is because of Impaired creation as in aplastic weakness. MPV is higher when there is decimation of platelets. This might be viewed as in incendiary inside sickness. In resistant thrombocytopenic purpura (ITP). In myeloproliferative maladies and Bernard-Soulier condition. It might likewise be identified with toxemia, and recuperation from transient hypoplasia.