Advances techniques have been used to develop novel drug delivery systems (NDDS) for plant actives and extracts. Nanotechnology for drug delivery has gained much interest as a way to improve the solubility problems. Nano suspensions and nanoparticles are part of nanotechnology. This may interacts with the body at molecular scales with a high degree of specificity and designed to achieve maximum therapeutic efficacy. The nano-formulations are reported to have remarkable advantages over conventional formulations of plant products which include enhancement of solubility, stability, protection from toxicity and enhancement of pharmacological activity. The present review highlights the development of nano-formulation of phytoconstituents, summarizes their formulation and biological activity.