ANTI-TUMOR ACTIVITY OF SWIETENIA MAHAGONI (L.) JACQ. LEAF EXTRACT AGAINST 3-METHYLCHOLANTHRENE (3-MC) INDUCED SOLID TUMOR IN MICE

B. Ramya Sree
Department of Biotechnology, Sree Vidyanikethan Engineering College, Tirupati
Jyothi M. Joy
Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati

Autoimmune diseases ,autoantibodies ,Antimicrobial Peptides ,

An attempt was made to confirm the earlier reported anticancer activity of Swietenia mahagoni leaf extract (SMLE) in Ehrlich’s ascites carcinoma in mice against 3-methylcholanthrene (3-MC) induced solid tumor in the calf muscle of mice. It was found that SMLE treated groups of mice showed marked reduction in the tumor growth with respect to the corresponding untreated control group of mice. Biochemical studies revealed that SMLE treatment in solid tumor bearing mice causes oxidative stress by the production and accumulation of oxygen free radicals leading to increased intra-metastatic lipid peroxidation which might ultimately lead to loss of integrity of spread tumor cells thus causing the anti-tumor effect

5 , 1 , 2015