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Issn  2249-7579
e Issn  2249-7579
Publisher JOURNAL OF PHARMACEUTICAL BIOLOGY

EVALUATION OF IN-VITRO ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC WHOLE PLANT EXTRACT OF BARRINGTONIA ACUTANGULA (L.)

B. Ramya Sree
Department of Biotechnology, Sree Vidyanikethan Engineering College, Tirupati
Jyothi M. Joy
Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati

Autoimmune diseases ,autoantibodies ,Antimicrobial Peptides ,

In the present study, the ethanolic extract of Barringtonia acutangula (L.) Gaertn. (Family: Lecythidaceae) were investigated for anti-inflammatory activity by HRBC method. The prevention of hypotonicity induced HRBC membrane lysis was taken a measure of anti-inflammatory activity. These extracts show biphasic effects. Their activities were compared with standard drug diclofenac. Barringtonia acutangula a widely growing plant has been reported to possess number of medicinal properties. The various parts of Barringtonia acutangula such as root, whole plant and seeds are documented to possess various medicinal properties. The findings of the study indicate that the ethanolic extract of Barringtonia acutangula possesses anti-inflammatory activity which is probably related to the inhibition of prostaglandin synthesis. This is a possible rationale for its folkloric use as an anti-inflammatory agent.

4 , 1 , 2014

54 - 56