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Issn  2249-7579
e Issn  2249-7579
Publisher JOURNAL OF PHARMACEUTICAL BIOLOGY

EVALUATION OF ANTI-INFLAMMATORY POTENTIAL OF KIGELIA PINNATA LEAF EXTRACT IN WISTAR RATS

B. Ramya Sree
Department of Biotechnology, Sree Vidyanikethan Engineering College, Tirupati
Jyothi M. Joy
Department of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati

Autoimmune diseases ,autoantibodies ,Antimicrobial Peptides ,

The main aim of the present study is to evaluate the anti-inflammatory activity of leaf extract of Kigelia pinnata on wistar rats. Anti-inflammatory activity of the leaf extract of Kigelia pinnata at a dose of 200mg/kg & 400mg/kg was evaluated against the standard drug indomethacin at a dose of 10 mg/kg i.p. Wistar rats of either sex of five numbers in each group was undertaken for study and evaluated by carrageenan-induced paw edema and cotton pellet-induced granuloma methods. Both doses of leaf extract of Kigelia pinnata has significant reduction in the carrageenan induced paw edema (P< 0.001) in a dose dependent manner (Table 1) when compared to control and shows the reduction of the weight of cotton pellet granuloma in a dose dependent manner (Table 2) in the cotton pellet induced granuloma model of inflammation in rats. The leaf extract of Kigelia pinnata have potential anti-inflammatory activity so, it can be recommened for further studies

2 , 1 , 2012

35 - 39