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Three-hundred and seventy clinical samples from different hospital sites were used for this study. Collected samples were all analyzed by standard bacteriological techniques for the presence of A. baumannii strains. Susceptibility studies were evaluated by the Kirby-Bauer disc diffusion method and the production of metallo-beta-lactamase (MBL) enzyme was phenotypically detected by the imipenem-EDTA method. A total of 80 A. baumannii isolates (21.6%) was recovered from the clinical samples. The result of susceptibility study showed that the clinical isolates of A. baumannii were highly resistant to tested antibiotics. Most of the isolated A. baumannii showed high resistant to more than 3 antibiotic class used; and this was remarkable for imipenem (66.7%), meropenem (66.7%), ofloxacin (14.3%), ciprofloxacin (23.8%), piperacillin (23.8%), gentamicin (14.3%), ticarcillin-clavulanate (23.8%), cefepime (9.5%) and amoxicillin-clavulanic acid (9.5). However, some of the antibiotics including aztreonam, ertapenem, ceftazidime, and ceftriaxone, were active against the A. baumannii isolates. All the A. baumannii strains isolated from the clinical specimens were negative for MBL production. Nosocomial pathogens including A. baumannii that are drug-resistant pose serious health problems because they limit therapeutic options for treatment. Thus, it is critical that the use of antimicrobial agents is controlled in our healthcare system to forestall the emergence of resistant organisms