The study evaluated the effects of aqueous extract of the alligator pepper dry seeds on the histology of the pituitary glands of lactating albino rats. A total of sixty lactating albino rats were used for the study. The rats which weighed between 197g and 200g were divided into four groups (A0, A1, A2 and A3) of fifteen rats each. Group A0 rats were used as the control and were fed normal rat chow and clean water only. Groups A1, A2 and A3 were administered 0.7mg/kg, 1.4mg/kg, and 2.8mg/kg body weight doses of aqueous extract of alligator pepper dry seeds respectively. The individual experimental rat groups received the treatments orally between the hours of 9am and 11am daily for twenty one days. At the end of the experimental period of three weeks, the animals were weighed again (with a view to ascertaining a possible weight gain or loss) and then sacrificed. The pituitary glands were then excised and subjected to routine histological processing for investigations. The results showed that the extent to which the alligator pepper aqueous extract affected the pituitary gland tissue was dose-dependent. The animals that received 2.8mg/kg body weight dose were most affected, as their tissues showed pronounced structural cellular changes from the control.