Cucurbita maxima is a short lived shrub which belongs to family Cucurbitaceae. Seeds are traditionally used as a bitter tonic, oil obtained used in debility nervous disorders. This study was intended to evaluate the CNS stimulant activity of crude drug extract. The activity was carried out by using swiss albino mice. Caffeine was used as a reference drug. The crude extract showed significant CNS stimulant activity in comparison to control group and result were comparable to the activity shown by reference drug.