This study examines the effect of various cassava diseases, varieties of cassava and different plots of land on the yield of cassava using Latin Square Design. Data from a design carried out by National Bureau of Statistics was used and the result of the analysis shows that there is no significant difference in the effects of various cassava diseases, varieties of cassava and different location on the number of cassava plant harvested, number of cassava tuber harvested and on the weight of cassava tubers harvested. This implies that the effect of the factors under study on the number of cassava plant harvested, number of cassava tubers harvested and weight of cassava tubers harvested and weight of cassava tubers harvested are equal