Swine flu is a kind of a respiratory disease which is common in pigs. The H1N1 virus is however not a strain which has been seen in the swine. The H1N1 virus is a combination of different viruses. It’s a mixture of the swine flu, the bird flue and the kind of flue common during the winter months and the fall, seen among the people in Northern America. Some strains of H1N1 are endemic in humans and cause a small fraction of all influenza-like illness and a large fraction of all seasonal influenza. Influenza A virus strains are categorized according to two proteins found on the surface of the virus: hemagglutinin (H) and neuraminidase (N). All influenza A viruses contains hemagglutinin and neuraminidase, but the structures of these proteins differ from strain to strain, due to rapid genetic mutation in the viral genome. This review describes the developing potential of neuraminidase inhibitors in treatment of influenza. Five drugs are currently available for the treatment or prophylaxis of influenza infections: amantadine, rimantadine, zanamivir [Relenza], oseltamivir [Tamiflu] and peramivir. Recent results show that human isolates can also demonstrate decreased sensitivity to oseltamivir and zanamivir with drift mutations in the NA remote from the active site. A new H1N1 vaccine is available from the fall of 2009.There is two types of swine flu vaccine. One is given as a shot, the other is nasal spray.The swine flu shot contains killed (inactive) viruses. The flu shot is approved for people age 6 months and older.