The plant Cissus vitiginea which comes under the family vitaceae. It is commonly known as south Indian Treebine .it is found in South India and Sri Lanka. It is the one of the important plant used in the treatment of healing wounds, swelling, and sprains. It is extremely valuable plant. The various parts of Cissus vitiginea including leaves, fruits, flowers, roots and bark having different pharmacological activities like antimicrobial, Anti-inflammatory, antioxidant, anticancer etc. due to the presence of many phytochemical constituents. Due to renewed interest in the plant derived products, we aim at the phytochemical studies on Cissus vitiginea parts and it’s evaluation as a anti -inflammatory drug. The anti inflammatory studies also showed good activity in higher concentration. The IC50 of stem ethanolic extract in protein denaturation test was found to be 122.89µg/ml and the IC50 of leaf ethanolic extract was found to be 233.383µg/ml, the IC50 of stem ethanolic extract in protienase inhibition test was found to be 53.7085 µg/ml and the leaf ethanolic extract was found to be 267.84µg/ml. From the results, it is concluded that flavonoids present in the Cissus vitiginea extract may be responsible for the activity.